Open AccessInterleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus
Author(s) -
Cliviany Borges da Silva,
Diego Alves Vieira,
Luisa Freitas de Melo,
Anna Luiza Soares Chagas,
Adriana Dias Gomes,
César Lúcio Lopes de Faria,
Rosângela Teixeira,
Dulciene Maria Magalhães Queiroz,
Gifone A. Rocha,
Maria Marta Sarquis Soares,
Juliana Maria Trindade Bezerra,
Luciana Diniz Silva
Publication year - 2020
Publication title -
world journal of hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 55
ISSN - 1948-5182
DOI - 10.4254/wjh.v12.i4.137
Subject(s) - medicine , gastroenterology , diabetes mellitus , type 2 diabetes mellitus , genotyping , single nucleotide polymorphism , snp genotyping , cirrhosis , type 2 diabetes , genotype , immunology , endocrinology , biochemistry , chemistry , gene
Chronic hepatitis C (CHC) is associated with type 2 diabetes mellitus. Although the pathogenesis remains to be elucidated, a growing evidence has suggested a role of pro-inflammatory immune response. Increased serum concentrations of Interleukin 6 (IL-6) have been associated with insulin resistance, type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C infection.