Open AccessAceclofenac-induced hepatotoxicity: An ameliorative effect ofTerminalia belliricafruit and ellagic acid
Author(s) -
Ashutosh Gupta,
Abhay K. Pandey
Publication year - 2020
Publication title -
world journal of hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 55
ISSN - 1948-5182
DOI - 10.4254/wjh.v12.i11.949
Subject(s) - medicine , ellagic acid , terminalia , traditional medicine , aceclofenac , pharmacology , antioxidant , polyphenol , biochemistry , chromatography , chemistry
Aceclofenac (ACF), a widely used nonsteroidal anti-inflammatory drug, has been associated with a number of severe cases of clinical hepatotoxicity. Terminalia bellirica, an evergreen tree, is known to have several ethnomedicinal uses including antioxidant and hepatoprotective effects. Hence T. bellirica fruit extracts and its phytoconstituent ellagic acid (EA) are expected to provide protection against oxidative stress and liver damage produced by long-term use of ACF.