Open AccessMetalloproteinase expression after desflurane preconditioning in hepatectomies: A randomized clinical trial
Author(s) -
Eleni Koraki,
Ioannis Mantzoros,
Christos Chatzakis,
Anna Gkiouliava,
Angeliki Cheva,
Athina Lavrentieva,
Freideriki Sifaki,
Helena Argiriadou,
Ισαάκ Κεσίσογλου,
Konstantinos Galanos-Demiris,
Stefanos Bitsianis,
Konstantinos Tsalis
Publication year - 2020
Publication title -
world journal of hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 55
ISSN - 1948-5182
DOI - 10.4254/wjh.v12.i11.1098
Subject(s) - medicine , desflurane , hepatectomy , anesthesia , propofol , randomized controlled trial , matrix metalloproteinase , antithrombin , ischemic preconditioning , reperfusion injury , surgery , ischemia , gastroenterology , heparin , resection
Hepatectomy with inflow occlusion results in ischemia-reperfusion injury; however, pharmacological preconditioning can prevent such injury and optimize the postoperative recovery of hepatectomized patients. The normal inflammatory response after a hepatectomy involves increased expression of metalloproteinases, which may signal pathologic hepatic tissue reformation.