Open AccessCirculating miR-21-5p level has limited prognostic value in patients with hepatocellular carcinoma and is influenced by renal function
Author(s) -
Martin Franck,
Cosima Thon,
Kerstin Schütte,
Peter Malfertheiner,
Alexander Link
Publication year - 2020
Publication title -
world journal of hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 55
ISSN - 1948-5182
DOI - 10.4254/wjh.v12.i11.1031
Subject(s) - medicine , hepatocellular carcinoma , renal function , value (mathematics) , oncology , gastroenterology , machine learning , computer science
MicroRNAs (miRNAs) have been suggested as biomarkers for malignant diseases including hepatocellular carcinoma (HCC). Specifically, hsa-miR-21-5p (miR-21) is among the most frequently deregulated miRNA in cancer. The diagnostic and prognostic value of miR-21 has been demonstrated in HCC tissue, mostly in the Asian population. Although the impact of various factors has been recently reported for circulating hsa-miR-122-5p (miR-122), at present only limited knowledge is available for miR-21.