Open AccessProlonged high-fat-diet feeding promotes non-alcoholic fatty liver disease and alters gut microbiota in mice
Author(s) -
Kandy T. Velázquez,
Reilly T. Enos,
Jackie E. Bader,
Alexander T. Sougiannis,
Meredith S. Carson,
Ioulia Chatzistamou,
James A. Carson,
Prakash Nagarkatti,
E. Angela Murphy
Publication year - 2019
Publication title -
world journal of hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 55
ISSN - 1948-5182
DOI - 10.4254/wjh.v11.i8.619
Subject(s) - medicine , steatosis , fatty liver , gut flora , obesity , adipose tissue , endocrinology , insulin resistance , fibrosis , inflammation , physiology , intermittent fasting , disease , gastroenterology , immunology
Non-alcoholic fatty liver disease (NAFLD) has become an epidemic largely due to the worldwide increase in obesity. While lifestyle modifications and pharmacotherapies have been used to alleviate NAFLD, successful treatment options are limited. One of the main barriers to finding safe and effective drugs for long-term use in NAFLD is the fast initiation and progression of disease in the available preclinical models. Therefore, we are in need of preclinical models that (1) mimic the human manifestation of NAFLD and (2) have a longer progression time to allow for the design of superior treatments.