Open AccessYoungest case of an early gastric cancer after successful eradication therapy
Author(s) -
Hironori Kaneko,
Ichiro Konuma,
Kuang-I Fu,
Satoshi Yamada,
Yutaka Suzuki,
Akira Miyazaki
Publication year - 2013
Publication title -
world journal of gastrointestinal endoscopy
Language(s) - English
Resource type - Journals
ISSN - 1948-5190
DOI - 10.4253/wjge.v5.i6.300
Subject(s) - medicine , esophagogastroduodenoscopy , intestinal metaplasia , helicobacter pylori , gastroenterology , cancer , gastrectomy , atrophic gastritis , urea breath test , adenocarcinoma , dysplasia , gastritis , endoscopy , helicobacter pylori infection
A 28-year-old woman visited our clinic with a chief complaint of epigastralgia. She had received successful Helicobacter pylori (H. pylori) eradication therapy 5 years before. We repeated esophagogastroduodenoscopy, and a discolored depressed area with reddish spots and converging folds, 20 mm in size, was detected. No atrophic change including intestinal metaplasia or nodular gastritis was seen endoscopically. Two endoscopic biopsies revealed undifferentiated adenocarcinoma. No H. pylori was found, and the (13)C-urea breath test was also negative. Abdominal computed tomography demonstrated no nodal involvement, distant metastasis or fluid collection. She underwent a laparoscopy-assisted distal gastrectomy. Histologically, the resected specimen revealed an early undifferentiated gastric cancer that had invaded deeply into the submucosal layer. Nodal involvement was histologically confirmed. No atrophic change or H. pylori infection was evident histologically. This is the youngest patient ever reported to have developed a node-positive early gastric cancer after eradication of H. pylori.