Open AccessEnhancing endothelial progenitor cell for clinical use
Author(s) -
Lei Ye,
KianKeong Poh
Publication year - 2015
Publication title -
world journal of stem cells
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.907
H-Index - 18
ISSN - 1948-0210
DOI - 10.4252/wjsc.v7.i6.894
Subject(s) - medicine , progenitor cell , biomarker , endothelial dysfunction , endothelial progenitor cell , disease , endothelial stem cell , bioinformatics , intensive care medicine , cardiology , stem cell , biology , microbiology and biotechnology , biochemistry , in vitro
Circulating endothelial progenitor cells (EPCs) have been demonstrated to correlate negatively with vascular endothelial dysfunction and cardiovascular risk factors. However, translation of basic research into the clinical practice has been limited by the lack of unambiguous and consistent definitions of EPCs and reduced EPC cell number and function in subjects requiring them for clinical use. This article critically reviews the definition of EPCs based on commonly used protocols, their value as a biomarker of cardiovascular risk factor in subjects with cardiovascular disease, and strategies to enhance EPCs for treatment of ischemic diseases.