Open AccessStructural properties of scaffolds: Crucial parameters towards stem cells differentiation
Author(s) -
Laleh GhasemiMobarakeh,
Molamma P. Prabhakaran,
Lingling Tian,
Elham Shamirzaei-Jeshvaghani,
Leila Dehghani,
Seeram Ramakrishna
Publication year - 2015
Publication title -
world journal of stem cells
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.907
H-Index - 18
ISSN - 1948-0210
DOI - 10.4252/wjsc.v7.i4.728
Subject(s) - scaffold , tissue engineering , stem cell , extracellular matrix , microbiology and biotechnology , regeneration (biology) , cellular differentiation , chemistry , nanotechnology , materials science , biomedical engineering , biology , engineering , biochemistry , gene
Tissue engineering is a multidisciplinary field that applies the principles of engineering and life-sciences for regeneration of damaged tissues. Stem cells have attracted much interest in tissue engineering as a cell source due to their ability to proliferate in an undifferentiated state for prolonged time and capability of differentiating to different cell types after induction. Scaffolds play an important role in tissue engineering as a substrate that can mimic the native extracellular matrix and the properties of scaffolds have been shown to affect the cell behavior such as the cell attachment, proliferation and differentiation. Here, we focus on the recent reports that investigated the various aspects of scaffolds including the materials used for scaffold fabrication, surface modification of scaffolds, topography and mechanical properties of scaffolds towards stem cells differentiation effect. We will present a more detailed overview on the effect of mechanical properties of scaffolds on stem cells fate.