Open AccessAdult stem-like cells in kidney
Author(s) -
Keiichi Hishikawa,
Osamu Takase,
Masahide Yoshikawa,
Taro Tsujimura,
Masaomi Nangaku,
Tsuyoshi Takato
Publication year - 2015
Publication title -
world journal of stem cells
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.907
H-Index - 18
ISSN - 1948-0210
DOI - 10.4252/wjsc.v7.i2.490
Subject(s) - renal stem cell , kidney , regeneration (biology) , induced pluripotent stem cell , stem cell , progenitor cell , biology , adult stem cell , microbiology and biotechnology , medicine , pathology , cellular differentiation , embryonic stem cell , endocrinology , gene , genetics
Human pluripotent cells are promising for treatment for kidney diseases, but the protocols for derivation of kidney cell types are still controversial. Kidney tissue regeneration is well confirmed in several lower vertebrates such as fish, and the repair of nephrons after tubular damages is commonly observed after renal injury. Even in adult mammal kidney, renal progenitor cell or system is reportedly presents suggesting that adult stem-like cells in kidney can be practical clinical targets for kidney diseases. However, it is still unclear if kidney stem cells or stem-like cells exist or not. In general, stemness is defined by several factors such as self-renewal capacity, multi-lineage potency and characteristic gene expression profiles. The definite use of stemness may be obstacle to understand kidney regeneration, and here we describe the recent broad findings of kidney regeneration and the cells that contribute regeneration.