Open AccessSubstrates for clinical applicability of stem cells
Author(s) -
Sanjar Enam
Publication year - 2015
Publication title -
world journal of stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.907
H-Index - 18
ISSN - 1948-0210
DOI - 10.4252/wjsc.v7.i2.243
Subject(s) - regenerative medicine , induced pluripotent stem cell , self healing hydrogels , stem cell , extracellular matrix , nanotechnology , embryonic stem cell , microbiology and biotechnology , biology , chemistry , materials science , biochemistry , organic chemistry , gene
The capability of human pluripotent stem cells (hPSCs) to differentiate into a variety of cells in the human body holds great promise for regenerative medicine. Many substrates exist on which hPSCs can be self-renewed, maintained and expanded to further the goal of clinical application of stem cells. In this review, we highlight numerous extracellular matrix proteins, peptide and polymer based substrates, scaffolds and hydrogels that have been pioneered. We discuss their benefits and shortcomings and offer future directions as well as emphasize commercially available synthetic peptides as a type of substrate that can bring the benefits of regenerative medicine to clinical settings.