Open AccessHuman induced pluripotent stem cells: A new source for brown and white adipocytes
Author(s) -
Anne-Laure Hafner,
Christian Dani
Publication year - 2014
Publication title -
world journal of stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.907
H-Index - 18
ISSN - 1948-0210
DOI - 10.4252/wjsc.v6.i4.467
Subject(s) - adipogenesis , mesenchymal stem cell , induced pluripotent stem cell , embryonic stem cell , human induced pluripotent stem cells , microbiology and biotechnology , regenerative medicine , biology , stem cell , genetics , gene
Mesenchymal stem cells (MSCs) derived from human induced pluripotent stem cells (hiPSCs) provide a novel source for generating adipocytes, thus opening new avenues for fundamental research and clinical medicine. We present the adipogenic potential of hiPSCs and the various methods to derive hiPSC-MSCs. We discuss the main characteristic of hiPSC-MSCs, which is their low adipogenic capacity as compared to adult-MSCs. Finally, we propose several hypotheses to explanation this feature, underlying a potential critical role of the micro-environment. We favour the hypothesis that the range of factors or culture conditions required to induce adipocyte differentiation of MSCs derived from adult tissues and from embryonic-like cells could differ.