Human induced pluripotent stem cells: A new source for brown and white adipocytes | Zendy

Anne-Laure Hafner | Zendy

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Human induced pluripotent stem cells: A new source for brown and white adipocytes

Author(s) -

Anne-Laure Hafner

Publication year - 2014

Publication title -

world journal of stem cells

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.907

H-Index - 18

ISSN - 1948-0210

DOI - 10.4252/wjsc.v6.i4.467

Subject(s) - adipogenesis , mesenchymal stem cell , induced pluripotent stem cell , embryonic stem cell , human induced pluripotent stem cells , microbiology and biotechnology , regenerative medicine , biology , stem cell , genetics , gene

Mesenchymal stem cells (MSCs) derived from human induced pluripotent stem cells (hiPSCs) provide a novel source for generating adipocytes, thus opening new avenues for fundamental research and clinical medicine. We present the adipogenic potential of hiPSCs and the various methods to derive hiPSC-MSCs. We discuss the main characteristic of hiPSC-MSCs, which is their low adipogenic capacity as compared to adult-MSCs. Finally, we propose several hypotheses to explanation this feature, underlying a potential critical role of the micro-environment. We favour the hypothesis that the range of factors or culture conditions required to induce adipocyte differentiation of MSCs derived from adult tissues and from embryonic-like cells could differ.

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