Open AccessEnhancing the efficacy of mesenchymal stem cell therapy
Author(s) -
Michalis Mastri,
Huey Lin,
Techung Lee
Publication year - 2014
Publication title -
world journal of stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.907
H-Index - 18
ISSN - 1948-0210
DOI - 10.4252/wjsc.v6.i2.82
Subject(s) - mesenchymal stem cell , stem cell therapy , stem cell , medicine , cell therapy , paracrine signalling , clinical trial , potency , pathology , biology , in vitro , microbiology and biotechnology , receptor , biochemistry
Mesenchymal stem cell (MSC) therapy is entering a challenging phase after completion of many preclinical and clinical trials. Among the major hurdles encountered in MSC therapy are inconsistent stem cell potency, poor cell engraftment and survival, and age/disease-related host tissue impairment. The recognition that MSCs primarily mediate therapeutic benefits through paracrine mechanisms independent of cell differentiation provides a promising framework for enhancing stem cell potency and therapeutic benefits. Several MSC priming approaches are highlighted, which will likely allow us to harness the full potential of adult stem cells for their future routine clinical use.