Open AccessDifferentiation of mesenchymal stem cells into gonad and adrenal steroidogenic cells
Author(s) -
Takashi Yazawa,
Yoshitaka Imamichi,
Kaoru Miyamoto,
Akihiro Umezawa,
Tadatsugu Taniguchi
Publication year - 2014
Publication title -
world journal of stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.907
H-Index - 18
ISSN - 1948-0210
DOI - 10.4252/wjsc.v6.i2.203
Subject(s) - mesenchymal stem cell , stem cell , steroidogenic factor 1 , nuclear receptor , biology , microbiology and biotechnology , hormone , adult stem cell , cellular differentiation , gonad , cancer research , steroid hormone , endocrinology , medicine , transcription factor , genetics , gene
Hormone replacement therapy is necessary for patients with adrenal and gonadal failure. Steroid hormone treatment is also employed in aging people for sex hormone deficiency. These patients undergo such therapies, which have associated risks, for their entire life. Stem cells represent an innovative tool for tissue regeneration and the possibility of solving these problems. Among various stem cell types, mesenchymal stem cells have the potential to differentiate into steroidogenic cells both in vivo and in vitro. In particular, they can effectively be differentiated into steroidogenic cells by expressing nuclear receptor 5A subfamily proteins (steroidogenic factor-1 and liver receptor homolog-1) with the aid of cAMP. This approach will provide a source of cells for future regenerative medicine for the treatment of diseases caused by steroidogenesis deficiencies. It can also represent a useful tool for studying the molecular mechanisms of steroidogenesis and its related diseases.