Open AccessCombination of mesenchymal stem cells and three-dimensional collagen scaffold preserves ventricular remodeling in rat myocardial infarction model
Author(s) -
RidaeMaria Qazi,
Irfan Khan,
Kanwal Haneef,
Tuba Shakil Malick,
Nadia Naeem,
Waqas Ahmad,
Asmat Salim,
Sadia Mohsin
Publication year - 2022
Publication title -
world journal of stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.907
H-Index - 18
ISSN - 1948-0210
DOI - 10.4252/wjsc.v14.i8.633
Subject(s) - mesenchymal stem cell , regeneration (biology) , stem cell , microbiology and biotechnology , cellular differentiation , tissue engineering , transplantation , pathology , cancer research , biology , medicine , biomedical engineering , biochemistry , gene
Cardiovascular diseases are the major cause of mortality worldwide. Regeneration of the damaged myocardium remains a challenge due to mechanical constraints and limited healing ability of the adult heart tissue. Cardiac tissue engineering using biomaterial scaffolds combined with stem cells and bioactive molecules could be a highly promising approach for cardiac repair. Use of biomaterials can provide suitable microenvironment to the cells and can solve cell engraftment problems associated with cell transplantation alone. Mesenchymal stem cells (MSCs) are potential candidates in cardiac tissue engineering because of their multilineage differentiation potential and ease of isolation. Use of DNA methyl transferase inhibitor, such as zebularine, in combination with three-dimensional (3D) scaffold can promote efficient MSC differentiation into cardiac lineage, as epigenetic modifications play a fundamental role in determining cell fate and lineage specific gene expression.