Open AccessInduced pluripotent stem cells as suitable sensors for fibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome
Author(s) -
María B Monzón-Nomdedeu,
Karl Morten,
Elisa Oltra
Publication year - 2021
Publication title -
world journal of stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.907
H-Index - 18
ISSN - 1948-0210
DOI - 10.4252/wjsc.v13.i8.1134
Subject(s) - chronic fatigue syndrome , fibromyalgia , medicine , encephalomyelitis , physical medicine and rehabilitation , induced pluripotent stem cell , neuroscience , physical therapy , psychology , multiple sclerosis , psychiatry , biology , biochemistry , embryonic stem cell , gene
Fibromyalgia (FM) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) are devastating metabolic neuroimmune diseases that are difficult to diagnose because of the presence of numerous symptoms and a lack of specific biomarkers. Despite patient heterogeneity linked to patient subgroups and variation in disease severity, anomalies are found in the blood and plasma of these patients when compared with healthy control groups. The seeming specificity of these "plasma factors", as recently reported by Ron Davis and his group at Stanford University, CA, United States, and observations by our group, have led to the proposal that induced pluripotent stem cells (iPSCs) may be used as metabolic sensors for FM and ME/CFS, a hypothesis that is the basis for this in-depth review.