Open AccessHypoxia-inducible factor-1α–mediated upregulation of CD99 promotes the proliferation of placental mesenchymal stem cells by regulating ERK1/2
Author(s) -
Xudong Feng,
Jiaqi Zhu,
Jiarong Zhou,
Feiyan Lin,
Bing Feng,
Xiaowei Shi,
Qiaoling Pan,
Jiong Yu,
Lanjuan Li,
Hong Cao
Publication year - 2021
Publication title -
world journal of stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.907
H-Index - 18
ISSN - 1948-0210
DOI - 10.4252/wjsc.v13.i4.317
Subject(s) - mesenchymal stem cell , small interfering rna , microbiology and biotechnology , cell growth , mapk/erk pathway , biology , gene knockdown , flow cytometry , cell cycle , chemistry , signal transduction , cell , cell culture , transfection , biochemistry , genetics
As human placenta-derived mesenchymal stem cells (hP-MSCs) exist in a physiologically hypoxic microenvironment, various studies have focused on the influence of hypoxia. However, the underlying mechanisms remain to be further explored.