Open AccessExosomes derived from inflammatory myoblasts promote M1 polarization and break the balance of myoblast proliferation/differentiation
Author(s) -
Zhiwen Luo,
Yaying Sun,
Jinrong Lin,
Beijie Qi,
Jiwu Chen
Publication year - 2021
Publication title -
world journal of stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.907
H-Index - 18
ISSN - 1948-0210
DOI - 10.4252/wjsc.v13.i11.1762
Subject(s) - c2c12 , myocyte , inflammation , microbiology and biotechnology , macrophage polarization , microvesicles , biology , macrophage , immunology , in vitro , myogenesis , microrna , biochemistry , gene
Acute muscle injuries are one of the most common injuries in sports. Severely injured muscles are prone to re-injury due to fibrotic scar formation caused by prolonged inflammation. How to regulate inflammation and suppress fibrosis is the focus of promoting muscle healing. Recent studies have found that myoblasts and macrophages play important roles in the inflammatory phase following muscle injury; however, the crosstalk between these two types of cells in the inflammatory environment, particularly the exosome-related mechanisms, had not been well studied.