Open AccessApplication of adipose-derived stem cells in treating fibrosis
Author(s) -
Zhujun Li,
Liquan Wang,
Yun-Zhu Li,
Chenyu Wang,
Jiuzuo Huang,
Nanze Yu,
Xiao Long
Publication year - 2021
Publication title -
world journal of stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.907
H-Index - 18
ISSN - 1948-0210
DOI - 10.4252/wjsc.v13.i11.1747
Subject(s) - fibrosis , regenerative medicine , adipose tissue , medicine , extracellular matrix , stem cell , angiogenesis , cancer research , bioinformatics , pathology , biology , microbiology and biotechnology
Fibrosis is the hyperactivation of fibroblasts that results in excessive accumulation of extracellular matrix, which is involved in numerous pathological changes and diseases. Adipose-derived stem cells (ASCs) are promising seed cells for regenerative medicine due to their bountiful source, low immunogenicity and lack of ethical issues. Their anti-fibrosis, immunomodulation, angiogenesis and other therapeutic effects have made them suitable for treating fibrosis-related diseases. Here, we review the literature on ASCs treating fibrosis, elaborate and discuss their mechanisms of action, changes in disease environment, ways to enhance therapeutic effects, as well as current preclinical and clinical studies, in order to provide a general picture of ASCs treating fibrotic diseases.