Open AccessRegulation of the mesenchymal stem cell fate by interleukin-17: Implications in osteogenic differentiation
Author(s) -
Jelena Krstić,
Slavko Mojsilović,
Sonja Mojsilović,
Juan F Santibanez
Publication year - 2021
Publication title -
world journal of stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.907
H-Index - 18
ISSN - 1948-0210
DOI - 10.4252/wjsc.v13.i11.1696
Subject(s) - mesenchymal stem cell , microbiology and biotechnology , stromal cell , cell fate determination , regeneration (biology) , stem cell , bone resorption , context (archaeology) , cellular differentiation , chemistry , biology , cancer research , transcription factor , endocrinology , biochemistry , paleontology , gene
Bone regeneration is a tightly regulated process that ensures proper repair and functionality after injury. The delicate balance between bone formation and resorption is governed by cytokines and signaling molecules released during the inflammatory response. Interleukin (IL)-17A, produced in the early phase of inflammation, influences the fate of osteoprogenitors. Due to their inherent capacity to differentiate into osteoblasts, mesenchymal stem/stromal cells (MSCs) contribute to bone healing and regeneration. This review presents an overview of IL-17A signaling and the leading cellular and molecular mechanisms by which it regulates the osteogenic differentiation of MSCs. The main findings demonstrating IL-17A's influence on osteoblastogenesis are described. To this end, divergent information exists about the capacity of IL-17A to regulate MSCs' osteogenic fate, depending on the tissue context and target cell type, along with contradictory findings in the same cell types. Therefore, we summarize the data showing both the pro-osteogenic and anti-osteogenic roles of IL-17, which may help in the understanding of IL-17A function in bone repair and regeneration.