Open AccessStem cell transplantation and/or adenoviral glial cell line-derived neurotrophic factor promote functional recovery in hemiparkinsonian rats
Author(s) -
Ming-Tzu Tsai,
Shih Chieh Hung,
Ching Feng Weng,
Su Fen Fan,
Dann Ying Liou,
Wen Cheng Huang,
Kang Du Liu,
Henrich Cheng
Publication year - 2021
Publication title -
world journal of stem cells
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.907
H-Index - 18
ISSN - 1948-0210
DOI - 10.4252/wjsc.v13.i1.78
Subject(s) - glial cell line derived neurotrophic factor , neurotrophic factors , transplantation , ciliary neurotrophic factor , stem cell , neuroscience , medicine , brain derived neurotrophic factor , biology , microbiology and biotechnology , receptor
Parkinson's disease (PD) is a neurological disorder characterized by the progressive loss of midbrain dopamine (DA) neurons. Bone marrow mesenchymal stem cells (BMSCs) can differentiate into multiple cell types including neurons and glia. Transplantation of BMSCs is regarded as a potential approach for promoting neural regeneration. Glial cell line-derived neurotrophic factor (GDNF) can induce BMSC differentiation into neuron-like cells. This work evaluated the efficacy of nigral grafts of human BMSCs (hMSCs) and/or adenoviral (Ad) GDNF gene transfer in 6-hydroxydopamine (6-OHDA)-lesioned hemiparkinsonian rats.