Open AccessInflammatory niche: Mesenchymal stromal cell priming by soluble mediators
Author(s) -
Aleksandra Jauković,
Тамара Кукољ,
Hristina Obradović,
Ivana Okić-Đorđević,
Slavko Mojsilović,
Diana Bugarski
Publication year - 2020
Publication title -
world journal of stem cells
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.907
H-Index - 18
ISSN - 1948-0210
DOI - 10.4252/wjsc.v12.i9.922
Subject(s) - mesenchymal stem cell , priming (agriculture) , stromal cell , microbiology and biotechnology , immune system , regeneration (biology) , cell therapy , stem cell , inflammation , cell , biology , immunology , medicine , cancer research , botany , germination , genetics
Mesenchymal stromal/stem cells (MSCs) are adult stem cells of stromal origin that possess self-renewal capacity and the ability to differentiate into multiple mesodermal cell lineages. They play a critical role in tissue homeostasis and wound healing, as well as in regulating the inammatory microenvironment through interactions with immune cells. Hence, MSCs have garnered great attention as promising candidates for tissue regeneration and cell therapy. Because the inflammatory niche plays a key role in triggering the reparative and immunomodulatory functions of MSCs, priming of MSCs with bioactive molecules has been proposed as a way to foster the therapeutic potential of these cells. In this paper, we review how soluble mediators of the inflammatory niche (cytokines and alarmins) influence the regenerative and immunomodulatory capacity of MSCs, highlighting the major advantages and concerns regarding the therapeutic potential of these inflammatory primed MSCs. The data summarized in this review may provide a significant starting point for future research on priming MSCs and establishing standardized methods for the application of preconditioned MSCs in cell therapy.