Open AccessRole of mesenchymal stem cell derived extracellular vesicles in autoimmunity: A systematic review
Author(s) -
Jinghua Wang,
Xiaoling Liu,
Junqiang Sun,
Jinghan Yang,
Dongmei Xu,
Shushan Yan
Publication year - 2020
Publication title -
world journal of stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.907
H-Index - 18
ISSN - 1948-0210
DOI - 10.4252/wjsc.v12.i8.879
Subject(s) - autoimmunity , immune system , acquired immune system , mesenchymal stem cell , immunology , innate immune system , biology , immunity , microvesicles , dendritic cell , medicine , microbiology and biotechnology , microrna , gene , biochemistry
Mesenchymal stem cells (MSCs) have been reported to possess immune regulatory effects in innate and adaptive immune reactions. MSCs can mediate intercellular communications by releasing extracellular vesicles (EVs), which deliver functional molecules to targeted cells. MSC derived EVs (MSC-EVs) confer altering effects on many immune cells, including T lymphocytes, B lymphocytes, natural killer cells, dendritic cells, and macrophages. A large number of studies have suggested that MSC-EVs participate in regulating autoimmunity related diseases. This characteristic of MSC-EVs makes them be potential biomarkers for the diagnosis and treatment of autoimmunity related diseases.