Open AccessMesenchymal stem cell-derived exosomes: Toward cell-free therapeutic strategies in regenerative medicine
Author(s) -
Zhanjun Ma,
Jingjing Yang,
Yubao Lu,
Zhaoyang Liu,
Xuexi Wang
Publication year - 2020
Publication title -
world journal of stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.907
H-Index - 18
ISSN - 1948-0210
DOI - 10.4252/wjsc.v12.i8.814
Subject(s) - microvesicles , regenerative medicine , mesenchymal stem cell , stem cell , medicine , cell therapy , regeneration (biology) , microbiology and biotechnology , cell , biology , pathology , microrna , biochemistry , genetics , gene
Mesenchymal stem cells (MSCs) are multipotent stem cells with marked potential for regenerative medicine because of their strong immunosuppressive and regenerative abilities. The therapeutic effects of MSCs are based in part on their secretion of biologically active factors in extracellular vesicles known as exosomes. Exosomes have a diameter of 30-100 nm and mediate intercellular communication and material exchange. MSC-derived exosomes (MSC-Exos) have potential for cell-free therapy for diseases of, for instance, the kidney, liver, heart, nervous system, and musculoskeletal system. Hence, MSC-Exos are an alternative to MSC-based therapy for regenerative medicine. We review MSC-Exos and their therapeutic potential for a variety of diseases and injuries.