Open AccessExosomes derived from stem cells as an emerging therapeutic strategy for intervertebral disc degeneration
Author(s) -
Zhilei Hu,
Haiyin Li,
Xian Chang,
Yueyang Li,
Chenhao Liu,
Xuerui Gao,
Zhengquan Yu,
Yuxuan Chen,
Changqing Li
Publication year - 2020
Publication title -
world journal of stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.907
H-Index - 18
ISSN - 1948-0210
DOI - 10.4252/wjsc.v12.i8.803
Subject(s) - microvesicles , degeneration (medical) , regenerative medicine , regeneration (biology) , intervertebral disc , medicine , stem cell , neuroscience , pathology , biology , microrna , microbiology and biotechnology , anatomy , biochemistry , gene
Intervertebral disc (IVD) degenerative diseases are a common problem in the world, and they cause substantial social and economic burdens for people. The current methods for treating IVD degenerative diseases mainly include surgery and conservative treatment, which cannot fundamentally restore the normal structure of the disc. With continuous research on the mechanism of degeneration and the development of regenerative medicine, rapid progress has been made in the field of regenerative medicine regarding the use of stem cell-derived exosomes, which are active biological substances used in intercellular communication, because they show a strong effect in promoting tissue regeneration. The study of exosomes in the field of IVD degeneration has just begun, and many surprising achievements have been made. This paper mainly reviews the biological characteristics of exosomes and highlights the current status of exosomes in the field of IVD degeneration, as well as future developments regarding exosomes.