Open AccessBone marrow mesenchymal stem cells induce M2 microglia polarization through PDGF-AA/MANF signaling
Author(s) -
Fan Yang,
Wenbin Li,
Yewei Qu,
Jinnan Gao,
Yushi Tang,
Dongjie Wang,
Yujun Pan
Publication year - 2020
Publication title -
world journal of stem cells
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.907
H-Index - 18
ISSN - 1948-0210
DOI - 10.4252/wjsc.v12.i7.633
Subject(s) - microglia , microbiology and biotechnology , mesenchymal stem cell , paracrine signalling , chemistry , biology , immunology , inflammation , biochemistry , receptor
Bone marrow mesenchymal stem cells (BMSCs) are capable of shifting the microglia/macrophages phenotype from M1 to M2, contributing to BMSCs-induced brain repair. However, the regulatory mechanism of BMSCs on microglia/macrophages after ischemic stroke is unclear. Recent evidence suggests that mesencephalic astrocyte-derived neurotrophic factor (MANF) and platelet-derived growth factor-AA (PDGF-AA)/MANF signaling regulate M1/M2 macrophage polarization.