Open AccessStem cell homing, tracking and therapeutic efficiency evaluation for stroke treatment using nanoparticles: A systematic review
Author(s) -
Mariana Penteado Nucci,
Igor Salerno Filgueiras,
João José Pinto Ferreira,
Fernando A. Oliveira,
Leopoldo Penteado Nucci,
Javier Bustamante Mamani,
Gabriel N. A. Rego,
Lionel Fernel Gamarra
Publication year - 2020
Publication title -
world journal of stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.907
H-Index - 18
ISSN - 1948-0210
DOI - 10.4252/wjsc.v12.i5.381
Subject(s) - homing (biology) , medicine , stroke (engine) , bioinformatics , pathology , mechanical engineering , ecology , engineering , biology
Stroke is the second leading cause of death worldwide. There is a real need to develop treatment strategies for reducing neurological deficits in stroke survivors, and stem cell (SC) therapeutics appear to be a promising alternative for stroke therapy that can be used in combination with approved thrombolytic or thrombectomy approaches. However, the efficacy of SC therapy depends on the SC homing ability and engraftment into the injury site over a long period of time. Nonetheless, tracking SCs from their niche to the target tissues is a complex process.