Open AccessCurrent and future uses of skeletal stem cells for bone regeneration
Author(s) -
Gaosi Xu,
Xiangfeng Zhang,
Lu Sun,
Erman Chen
Publication year - 2020
Publication title -
world journal of stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.907
H-Index - 18
ISSN - 1948-0210
DOI - 10.4252/wjsc.v12.i5.339
Subject(s) - stem cell , nonunion , regeneration (biology) , microbiology and biotechnology , mesenchymal stem cell , bone healing , progenitor cell , multipotent stem cell , cartilage , stem cell transplantation for articular cartilage repair , endochondral ossification , medicine , biology , anatomy , adult stem cell , cellular differentiation , biochemistry , gene
The postnatal skeleton undergoes growth, modeling, and remodeling. The human skeleton is a composite of diverse tissue types, including bone, cartilage, fat, fibroblasts, nerves, blood vessels, and hematopoietic cells. Fracture nonunion and bone defects are among the most challenging clinical problems in orthopedic trauma. The incidence of nonunion or bone defects following fractures is increasing. Stem and progenitor cells mediate homeostasis and regeneration in postnatal tissue, including bone tissue. As multipotent stem cells, skeletal stem cells (SSCs) have a strong effect on the growth, differentiation, and repair of bone regeneration. In recent years, a number of important studies have characterized the hierarchy, differential potential, and bone formation of SSCs. Here, we describe studies on and applications of SSCs and/or mesenchymal stem cells for bone regeneration.