Open AccessAdvances in treatment of neurodegenerative diseases: Perspectives for combination of stem cells with neurotrophic factors
Author(s) -
Jie Wang,
Weiwei Hu,
Zhi Jiang,
Ming Feng
Publication year - 2020
Publication title -
world journal of stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.907
H-Index - 18
ISSN - 1948-0210
DOI - 10.4252/wjsc.v12.i5.323
Subject(s) - amyotrophic lateral sclerosis , medicine , neurotrophic factors , disease , stem cell , neuroscience , microvesicles , neurotrophin , huntington's disease , population , mesenchymal stem cell , bioinformatics , pathology , biology , microrna , biochemistry , receptor , environmental health , gene , genetics
Neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis, are a group of incurable neurological disorders, characterized by the chronic progressive loss of different neuronal subtypes. However, despite its increasing prevalence among the ever-increasing aging population, little progress has been made in the coincident immense efforts towards development of therapeutic agents. Research interest has recently turned towards stem cells including stem cells-derived exosomes, neurotrophic factors, and their combination as potential therapeutic agents in neurodegenerative diseases. In this review, we summarize the progress in therapeutic strategies based on stem cells combined with neurotrophic factors and mesenchymal stem cells-derived exosomes for neurodegenerative diseases, with an emphasis on the combination therapy.