Open AccessAbility of human umbilical cord mesenchymal stem cells to repair chemotherapy-induced premature ovarian failure
Author(s) -
Jian Shen,
Dai Cao,
Jingli Sun
Publication year - 2020
Publication title -
world journal of stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.907
H-Index - 18
ISSN - 1948-0210
DOI - 10.4252/wjsc.v12.i4.277
Subject(s) - premature ovarian failure , medicine , umbilical cord , ovary , premature ovarian insufficiency , stem cell , estrous cycle , mesenchymal stem cell , cyclophosphamide , andrology , endocrinology , chemotherapy , biology , pathology , immunology , genetics
Premature ovarian insufficiency (POI) and premature ovarian failure (POF) have become one of the major problems threatening women of childbearing age. Studies have shown that stem cells transplanted from bone marrow, umbilical cord, peripheral blood and amniotic fluid can migrate and proliferate to the ovary, promote ovarian function repair, increase the number of follicles and granulosa cells at all levels of ovary, improve endocrine function, and can differentiate into oocytes in specific ovarian environment to restore fertility to some extent.