Open AccessClonal isolation of endothelial colony-forming cells from early gestation chorionic villi of human placenta for fetal tissue regeneration
Author(s) -
Kewa Gao,
Siqi He,
Priyadarsini Kumar,
Diana L. Farmer,
Jianda Zhou,
Aijun Wang
Publication year - 2020
Publication title -
world journal of stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.907
H-Index - 18
ISSN - 1948-0210
DOI - 10.4252/wjsc.v12.i2.123
Subject(s) - chorionic villi , placenta , regeneration (biology) , fetus , trophoblast , gestation , isolation (microbiology) , andrology , intervillous space , biology , medicine , pathology , anatomy , pregnancy , microbiology and biotechnology , bioinformatics , genetics
Endothelial colony-forming cells (ECFCs) have been implicated in the process of vascularization, which includes vasculogenesis and angiogenesis. Vasculogenesis is a de novo formation of blood vessels, and is an essential physiological process that occurs during embryonic development and tissue regeneration. Angiogenesis is the growth of new capillaries from pre-existing blood vessels, which is observed both prenatally and postnatally. The placenta is an organ composed of a variety of fetal-derived cells, including ECFCs, and therefore has significant potential as a source of fetal ECFCs for tissue engineering.