Open AccessImmunophenotypic characteristics of multipotent mesenchymal stromal cells that affect the efficacy of their use in the prevention of acute graft vs host disease
Author(s) -
Nataliya Petinati,
Nikolay Kapranov,
Yulia Davydova,
Alexey Bigildeev,
О. С. Пшеничникова,
Dmitriy Karpenko,
Drize Ni,
Л А Кузьмина,
Е Н Паровичникова,
В Г Савченко
Publication year - 2020
Publication title -
world journal of stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.907
H-Index - 18
ISSN - 1948-0210
DOI - 10.4252/wjsc.v12.i11.1377
Subject(s) - mesenchymal stem cell , affect (linguistics) , stromal cell , medicine , disease , pathology , psychology , communication
Multipotent mesenchymal stromal cells (MSCs) are widely used in the clinic due to their unique properties, namely, their ability to differentiate in all mesenchymal directions and their immunomodulatory activity. Healthy donor MSCs were used to prevent the development of acute graft vs host disease (GVHD) after allogeneic bone marrow transplantation (allo-BMT). The administration of MSCs to patients was not always effective. The MSCs obtained from different donors have individual characteristics. The differences between MSC samples may affect their clinical efficacy.