Open AccessEnrichment of retinal ganglion and Müller glia progenitors from retinal organoids derived from human induced pluripotent stem cells - possibilities and current limitations
Author(s) -
Kristine Karla Freude,
Sarkis Saruhanian,
Alanna McCauley,
Colton Paterson,
Madeleine Odette,
Annika Oostenink,
Poul Hyttel,
Mark C Gillies,
Henriette Haukedal,
Miriam Kolko
Publication year - 2020
Publication title -
world journal of stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.907
H-Index - 18
ISSN - 1948-0210
DOI - 10.4252/wjsc.v12.i10.1171
Subject(s) - organoid , microbiology and biotechnology , biology , progenitor cell , retinal , muller glia , retina , induced pluripotent stem cell , cell sorting , stem cell , retinal ganglion cell , cell type , neuroscience , cell , embryonic stem cell , genetics , biochemistry , gene
Retinal organoids serve as excellent human-specific disease models for conditions affecting otherwise inaccessible retinal tissue from patients. They permit the isolation of key cell types affected in various eye diseases including retinal ganglion cells (RGCs) and Müller glia.