Open AccessStem cell-based therapies for fertility preservation in males: Current status and future prospects
Author(s) -
Hanchao Liu,
Yizhen Xie,
Chao Deng,
Guihua Liu
Publication year - 2020
Publication title -
world journal of stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.907
H-Index - 18
ISSN - 1948-0210
DOI - 10.4252/wjsc.v12.i10.1097
Subject(s) - stem cell , fertility preservation , fertility , organoid , extracellular vesicles , mesenchymal stem cell , biology , adult stem cell , male fertility , microbiology and biotechnology , medicine , cellular differentiation , population , biochemistry , environmental health , gene
With the decline in male fertility in recent years, strategies for male fertility preservation have received increasing attention. In this study, by reviewing current treatments and recent publications, we describe research progress in and the future directions of stem cell-based therapies for male fertility preservation, focusing on the use of spermatogonial stem cells (SSCs), SSC niches, SSC-based testicular organoids, other stem cell types such as mesenchymal stem cells, and stem cell-derived extracellular vesicles. In conclusion, a more comprehensive understanding of the germ cell microenvironment, stem cell-derived extracellular vesicles, and testicular organoids will play an important role in achieving male fertility preservation.