Open AccessStromal cell-derived factor-1α promotes recruitment and differentiation of nucleus pulposus-derived stem cells
Author(s) -
Jinwei Ying,
Tianyong Wen,
Shishen Pei,
Linghao Su,
Dike Ruan
Publication year - 2019
Publication title -
world journal of stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.907
H-Index - 18
ISSN - 1948-0210
DOI - 10.4252/wjsc.v11.i3.196
Subject(s) - chondrogenesis , aggrecan , microbiology and biotechnology , stromal cell , stem cell , extracellular matrix , cxcr4 , mesenchymal stem cell , stromal cell derived factor 1 , chemistry , cellular differentiation , chemokine , pathology , biology , immunology , medicine , inflammation , biochemistry , alternative medicine , osteoarthritis , articular cartilage , gene
Intervertebral disc (IVD) degeneration is a condition characterized by a reduction in the water and extracellular matrix content of the nucleus pulposus (NP) and is considered as one of the dominating contributing factors to low back pain. Recent evidence suggests that stromal cell-derived factor 1α (SDF-1α) and its receptor C-X-C chemokine receptor type 4 (CXCR4) direct the migration of stem cells associated with injury repair in different musculoskeletal tissues.