Open AccessAmeliorating liver fibrosis in an animal model using the secretome released from miR-122-transfected adipose-derived stem cells
Author(s) -
Kee-Hwan Kim,
Jaeim Lee,
Ok-Hee Kim,
Ha-Eun Hong,
Bong Jun Kwak,
Ho Joong Choi,
Joseph Ahn,
Tae Yun Lee,
Sang Chul Lee,
Say-June Kim
Publication year - 2019
Publication title -
world journal of stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.907
H-Index - 18
ISSN - 1948-0210
DOI - 10.4252/wjsc.v11.i11.990
Subject(s) - transfection , mesenchymal stem cell , proinflammatory cytokine , adipose tissue , stromal cell , microbiology and biotechnology , chemistry , secretory protein , stem cell , biology , inflammation , cancer research , immunology , secretion , biochemistry , gene
Recently, the exclusive use of mesenchymal stem cell (MSC)-secreted molecules, called secretome, rather than cells, has been evaluated for overcoming the limitations of cell-based therapy, while maintaining its advantages. However, the use of naïve secretome may not fully satisfy the specificity of each disease. Therefore, it appears to be more advantageous to use the functionally reinforced secretome through a series of processes involving physico-chemical adjustments or genetic manipulation rather than to the use naïve secretome.