Effects of nanotopography on stem cell phenotypes | Zendy

R. Ravichandran | Zendy

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Effects of nanotopography on stem cell phenotypes

Author(s) -

R. Ravichandran

Publication year - 2009

Publication title -

world journal of stem cells

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.907

H-Index - 18

ISSN - 1948-0210

DOI - 10.4252/wjsc.v1.i1.55

Subject(s) - nanotopography , stem cell , microbiology and biotechnology , extracellular matrix , phenotype , cell adhesion , cell , somatic cell , biology , cellular differentiation , biochemistry , gene

Stem cells are unspecialized cells that can self renew indefinitely and differentiate into several somatic cells given the correct environmental cues. In the stem cell niche, stem cell-extracellular matrix (ECM) interactions are crucial for different cellular functions, such as adhesion, proliferation, and differentiation. Recently, in addition to chemical surface modifications, the importance of nanometric scale surface topography and roughness of biomaterials has increasingly becoming recognized as a crucial factor for cell survival and host tissue acceptance in synthetic ECMs. This review describes the influence of nanotopography on stem cell phenotypes.

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