Open AccessNeo-adjuvant chemo(radio)therapy in gastric cancer: Current status and future perspectives
Author(s) -
Alberto Biondi,
Maria Carmen Lirosi,
Domenico D’Ugo,
Valeria Fico,
Riccardo Ricci,
Francesco Santullo,
Antonia Rizzuto,
Ferdinando Carlo Maria Cananzi,
Roberto Persiani
Publication year - 2015
Publication title -
world journal of gastrointestinal oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 26
ISSN - 1948-5204
DOI - 10.4251/wjgo.v7.i12.389
Subject(s) - medicine , cancer , clinical trial , chemotherapy , oncology , regimen , neoadjuvant therapy , randomized controlled trial , radiation therapy , adjuvant , gastric adenocarcinoma , adenocarcinoma , surgery , medical physics , intensive care medicine , breast cancer
In the last 20 years, several clinical trials on neoadjuvant chemotherapy and chemo-radiotherapy as a therapeutic approach for locally advanced gastric cancer have been performed. Even if more data are necessary to define the roles of these approaches, the results of preoperative treatments in the combined treatment of gastric adenocarcinoma are encouraging because this approach has led to a higher rate of curative surgical resection. Owing to the results of most recent randomized phase III studies, neoadjuvant chemotherapy for locally advanced resectable gastric cancer has satisfied the determination of level I evidence. Remaining concerns pertain to the choice of the optimal therapy regimen, strict patient selection by accurate pre-operative staging, standardization of surgical procedures, and valid criteria for response evaluation. New well-designed trials will be necessary to find the best therapeutic approach in pre-operative settings and the best way to combine old-generation chemotherapeutic drugs with new-generation molecules.