Open AccessComplete remission of advanced hepatocellular carcinoma by sorafenib: A case report
Author(s) -
Min Su Kim,
Young–Joo Jin,
Jin Woo Lee,
Jung-Il Lee,
Young Soo Kim,
Sun Young Lee,
Myoung Hun Chae
Publication year - 2013
Publication title -
world journal of gastrointestinal oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 26
ISSN - 1948-5204
DOI - 10.4251/wjgo.v5.i2.38
Subject(s) - sorafenib , medicine , hepatocellular carcinoma , discontinuation , cirrhosis , gastroenterology , portal vein thrombosis , carcinoma , surgery
Hepatocellular carcinoma (HCC) is the fifth most common malignant disease worldwide, and curative treatment remains difficult because the majority of cases are diagnosed in the advanced stage. Sorafenib is the only known effective systemic treatment, but patients rarely achieve complete remission (CR). A 66-year-old man with a history of alcoholic liver cirrhosis with a diagnosis of advanced HCC, was initially treated with transarterial chemoembolization on four occasions. However, the disease progressed with portal vein thrombosis. Therefore, sorafenib was started, and 4 mo later, the patient achieved CR. The treatment was continued for 12 mo, and CR was maintained up to 4 mo after sorafenib discontinuation.