Open AccessO6-methylguanine DNA methyltransferase is upregulated in malignant transformation of gastric epithelial cells via its gene promoter DNA hypomethylation
Author(s) -
Yuexia Chen,
Lulu He,
Xueping Xiang,
Jing Shen,
Hongyan Qi
Publication year - 2022
Publication title -
world journal of gastrointestinal oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 26
ISSN - 1948-5204
DOI - 10.4251/wjgo.v14.i3.664
Subject(s) - carcinogenesis , microbiology and biotechnology , dna methylation , methylation , malignant transformation , o 6 methylguanine dna methyltransferase , methyltransferase , cancer research , biology , dna methyltransferase , gene expression , chemistry , gene , biochemistry
O 6 -methylguanine-DNA methyltransferase (MGMT) is a suicide enzyme that repairs the mispairing base O 6 -methyl-guanine induced by environmental and experimental carcinogens. It can transfer the alkyl group to a cysteine residue in its active site and became inactive. The chemical carcinogen N-nitroso compounds (NOCs) can directly bind to the DNA and induce the O 6 -methylguanine adducts, which is an important cause of gene mutation and tumorigenesis. However, the underlying regulatory mechanism of MGMT involved in NOCs-induced tumorigenesis, especially in the initiation phase, remains largely unclear.