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O 6 -methylguanine-DNA methyltransferase (MGMT) is a suicide enzyme that repairs the mispairing base O 6 -methyl-guanine induced by environmental and experimental carcinogens. It can transfer the alkyl group to a cysteine residue in its active site and became inactive. The chemical carcinogen N-nitroso compounds (NOCs) can directly bind to the DNA and induce the O 6 -methylguanine adducts, which is an important cause of gene mutation and tumorigenesis. However, the underlying regulatory mechanism of MGMT involved in NOCs-induced tumorigenesis, especially in the initiation phase, remains largely unclear.

world journal of gastrointestinal oncology

O<sup>6</sup>-methylguanine DNA methyltransferase is upregulated in malignant transformation of gastric epithelial cells <i>via</i> its gene promoter DNA hypomethylation

O6-methylguanine DNA methyltransferase is upregulated in malignant transformation of gastric epithelial cells via its gene promoter DNA hypomethylation

O⁶-methylguanine DNA methyltransferase is upregulated in malignant transformation of gastric epithelial cells via its gene promoter DNA hypomethylation