Open AccessClinical significance of molecular subtypes of gastrointestinal tract adenocarcinoma
Author(s) -
Ekaterina Ignatova,
Э. И. Козлов,
М. В. Иванов,
Vladislav Mileyko,
Sofia Menshikova,
Henian Sun,
Mikhail Fedyanin,
Alexey Tryakin,
И. С. Стилиди
Publication year - 2022
Publication title -
world journal of gastrointestinal oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 26
ISSN - 1948-5204
DOI - 10.4251/wjgo.v14.i3.628
Subject(s) - subtyping , medicine , gastrointestinal tract , gastrointestinal cancer , adenocarcinoma , colorectal cancer , esophagus , stomach , microsatellite instability , oncology , cancer , biology , gene , genetics , allele , computer science , microsatellite , programming language
Adenocarcinomas of the gastrointestinal tract (esophagus, stomach, and colon) represent a heterogeneous group of diseases with distinct etiology, clinical features, treatment approaches, and prognosis. Studies are ongoing to isolate molecular genetic subtypes, perform complete biological characterization of the tumor, determine prognostic groups, and find predictive markers to the effectiveness of therapy. Separate molecular genetic classifications were created for esophageal adenocarcinoma [The Cancer Genome Atlas (TCGA)], stomach cancer (TCGA, Asian Cancer Research Group), and colon cancer (Colorectal Cancer Subtyping Consortium). In 2018, isolation of TCGA molecular genetic subtypes for adenocarcinomas of the gastrointestinal tract (esophagus, stomach, and colon) highlighted the need for further studies and clinical validation of subtyping of gastrointestinal adenocarcinomas. However, this approach has limitations. The aim of our work was to critically analyze integration of molecular genetic subtyping of gastrointestinal adenocarcinomas in clinical practice.