Open AccessSTAT3-mediated activation of mitochondrial pathway contributes to antitumor effect of dihydrotanshinone I in esophageal squamous cell carcinoma cells
Author(s) -
Mingming Qi,
Pengzhan He,
Lan Zhang,
Weiguo Dong
Publication year - 2021
Publication title -
world journal of gastrointestinal oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 26
ISSN - 1948-5204
DOI - 10.4251/wjgo.v13.i8.893
Subject(s) - medicine , cancer research , basal cell , esophageal squamous cell carcinoma , stat3 , apoptosis , cell , carcinoma , pathology , biochemistry , biology
Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies with a poor prognosis, and its treatment remains a great challenge. Dihydrotanshinone I (DHTS) has been reported to exert antitumor effect in many cancers. However, the role of DHTS in ESCC remains unclear.