Open AccessSurvival effect of probiotics in a rat model of colorectal cancer treated with capecitabine
Author(s) -
Graciela Gigola,
Pedro Carriere,
María Belén Novoa Díaz,
Gabriela Perdigón,
Ariel Osvaldo Zwenger,
Claudia Gentili
Publication year - 2021
Publication title -
world journal of gastrointestinal oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 26
ISSN - 1948-5204
DOI - 10.4251/wjgo.v13.i10.1518
Subject(s) - capecitabine , medicine , colorectal cancer , gastroenterology , statistical significance , oncology , cancer
Probiotics are used to manage a number of gastrointestinal disorders due to their beneficial properties. Clinical reports showed that probiotics also improve the life quality of patients with colorectal cancer (CRC) subjected to oncologic treatment. In a CRC animal model, probiotics supplementation has the potential to decrease the formation of aberrant crypts and ameliorate tumor malignancy, enhancing the antitumor effect of 5-fluorouracil (5-FU) chemotherapy. Based on these data, we hypothesize that the administration of probiotics impact positively in the overall survival and life quality of rats with CRC under the treatment of capecitabine, which is the pro drug of 5-FU.