Open AccessMethylation changes at the GNAS imprinted locus in pancreatic cystic neoplasms are important for the diagnosis of malignant cysts
Author(s) -
Sandra Faias,
Marlene Duarte,
Luísa Pereira,
Paula Chaves,
Marília Cravo,
António Dias Pereira,
Cristina Albuquerque
Publication year - 2020
Publication title -
world journal of gastrointestinal oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 26
ISSN - 1948-5204
DOI - 10.4251/wjgo.v12.i9.1056
Subject(s) - gnas complex locus , medicine , methylation , locus (genetics) , cyst , kras , cancer research , pancreatic cancer , pathology , cdkn2a , endoscopic ultrasound , biology , cancer , genetics , gene , radiology , colorectal cancer
Guanine nucleotide-binding protein, alpha stimulating ( GNAS ) mutations are characteristic of intraductal papillary mucinous neoplasms (IPMNs). Pancreatic ductal adenocarcinomas (PDACs) harboring GNAS mutations originate in IPMNs. GNAS is a complex imprinted locus that produces five transcripts regulated by differential methylated regions, NESP55 , GNASAS , GNASXL , GNAS1A , and GNAS .