Open AccessInterleukin-1 receptor antagonist enhances chemosensitivity to fluorouracil in treatment of Kras mutant colon cancer
Author(s) -
Yan Yan,
Hongwei Lin,
Zhuang Zhang,
Ming Li,
Shu Guo
Publication year - 2020
Publication title -
world journal of gastrointestinal oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 26
ISSN - 1948-5204
DOI - 10.4251/wjgo.v12.i8.877
Subject(s) - cancer research , downregulation and upregulation , cell growth , medicine , colorectal cancer , kras , cell culture , cancer , pharmacology , biology , biochemistry , genetics , gene
Kras mutant colon cancer shows abnormal activation of the nuclear factor kappa-B (NF-κB) pathway, resulting in the proliferation of tumor cells. Treatment with fluorouracil (5-FU) might not achieve the expected inhibition of proliferation of malignant cells based on the fluorouracil-induced activation of the NF-κB pathway.