Open AccessMaspin subcellular expression in wild-type and mutant TP53 gastric cancers
Author(s) -
Simona Gurzu,
Ioan Jung,
Haruhiko Sugimura,
Raluca Ioana Ștefan-van Staden,
Hidetaka Yamada,
Hiroko Natsume,
Yuji Iwashita,
Rita Szodorai,
János Szederjesi
Publication year - 2020
Publication title -
world journal of gastrointestinal oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 26
ISSN - 1948-5204
DOI - 10.4251/wjgo.v12.i7.741
Subject(s) - maspin , subcellular localization , exon , mutant , gene knockdown , cancer research , gene , wild type , suppressor , tumor suppressor gene , medicine , immunohistochemistry , cancer , mutation , biology , pathology , carcinogenesis , metastasis , genetics
Although the role of p53 in the evolution and prognosis of gastric cancer (GC) has been extensively examined, the exact mechanism of action is incompletely understood. In the last years, p53-target genes were supposed to be involved in the p53 pathway. One of them is the tumor-suppressor gene Maspin, which codifies the protein with the same name. Maspin activity depends on its subcellular localization. To our knowledge, the possible role of TP53 gene in Maspin subcellular localization, in GC cells, has not yet been studied in a large number of human samples.