Open AccessIdentification of integrin β6 gene promoter and analysis of its transcription regulation in colon cancer cells
Author(s) -
Wei Niu,
Qiyu Bo,
Jun Ni,
Zhihong Niu,
Cheng Pan,
Xueqing Zou,
Zhaoyang Zhang
Publication year - 2020
Publication title -
world journal of gastrointestinal oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 26
ISSN - 1948-5204
DOI - 10.4251/wjgo.v12.i5.526
Subject(s) - promoter , integrin, beta 6 , transcription factor , integrin , transcription (linguistics) , e box , response element , biology , transcriptional regulation , microbiology and biotechnology , gene , gene expression , genetics , cell , linguistics , philosophy
The integrin β6 gene, which is expressed in epithelial cancer, plays a pivotal role in various aspects of cancer progression. The present research for integrin β6 regulation mainly focuses on the post-transcription and translation related regulation mechanism and its role in tumorigenesis. The mechanisms of how the integrin β6 gene is regulated transcriptionally, and the promoter and transcription factors responsible for basic transcription of integrin β6 gene remain unknown.