Open AccessFree fatty acids receptors 2 and 3 control cell proliferation by regulating cellular glucose uptake
Author(s) -
Saeed Al Mahri,
Amal Al Ghamdi,
Maaged Akiel,
Monira Al Aujan,
Sameer Mohammad,
Mohammad Azhar Aziz
Publication year - 2020
Publication title -
world journal of gastrointestinal oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 26
ISSN - 1948-5204
DOI - 10.4251/wjgo.v12.i5.514
Subject(s) - gene knockdown , glucose homeostasis , receptor , cell growth , cell culture , microarray analysis techniques , medicine , biology , microbiology and biotechnology , biochemistry , gene expression , endocrinology , gene , genetics , diabetes mellitus , insulin resistance
Colorectal cancer (CRC) is a worldwide problem, which has been associated with changes in diet and lifestyle pattern. As a result of colonic fermentation of dietary fibres, short chain free fatty acids are generated which activate free fatty acid receptors (FFAR) 2 and 3. FFAR2 and FFAR3 genes are abundantly expressed in colonic epithelium and play an important role in the metabolic homeostasis of colonic epithelial cells. Earlier studies point to the involvement of FFAR2 in colorectal carcinogenesis.