Open AccessCancer-related microangiopathic hemolytic anemia in patients with advanced gastric cancer: A retrospective single-center analysis
Author(s) -
Anne Berger,
Michael Allgäuer,
Leonidas Apostolidis,
Anna Elisa Schulze-Schleithoff,
Uta Merle,
Dirk Jaeger,
Georg Martin Haag
Publication year - 2020
Publication title -
world journal of gastrointestinal oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 26
ISSN - 1948-5204
DOI - 10.4251/wjgo.v12.i11.1288
Subject(s) - medicine , microangiopathic hemolytic anemia , cancer , single center , anemia , retrospective cohort study , gastroenterology , oncology , thrombotic thrombocytopenic purpura , platelet
Microangiopathic hemolytic anemia (MAHA) with thrombocytopenia and organ failure caused by tumor-associated thrombotic microangiopathy (TMA) is a life-threatening oncological emergency. Rapid diagnosis and precise distinction from other forms of TMA is crucial for appropriate therapy, which aims at treating the underlying malignancy. However, the prognosis of patients with cancer-related (CR)-MAHA is limited. To date, less than 50 patients with gastric cancer and CR-MAHA have been reported, mainly as single case reports, and detailed information on treatment strategies and outcome are scarce. We analyzed the characteristics and outcomes data of CR-MAHA patients with gastric cancer treated at our center between 2012 and 2019.