Open AccessAbnormal CD44 activation of hepatocytes with nonalcoholic fatty accumulation in rat hepatocarcinogenesis
Author(s) -
Fei Miao,
Min Yao,
Jie Yang,
Wenjie Zheng,
Li Wang,
Dengfu Yao
Publication year - 2020
Publication title -
world journal of gastrointestinal oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 26
ISSN - 1948-5204
DOI - 10.4251/wjgo.v12.i1.66
Subject(s) - nonalcoholic fatty liver disease , hepatocellular carcinoma , medicine , cd44 , cirrhosis , triglyceride , fatty liver , h&e stain , alanine transaminase , endocrinology , oil red o , pathology , immunohistochemistry , cholesterol , chemistry , biochemistry , disease , adipose tissue , in vitro , adipogenesis
Prevalence of nonalcoholic fatty liver disease (NAFLD) is rapidly increasing, and NAFLD has become one of the most common chronic liver diseases worldwide. With abnormal CD44 activation, the severe form of NAFLD can progress to liver cirrhosis and hepatocellular carcinoma (HCC). Thus, the molecular mechanism of CD44 in NAFLD needs to be identified.