Open AccessRelationship between cachexia and perineural invasion in pancreatic adenocarcinoma
Author(s) -
Livia Petrusel,
Ioana Rusu,
Daniel Leucuţa,
Radu Seicean,
Ramona Suharoschi,
Paula Zamfir,
Andrada Seicean
Publication year - 2019
Publication title -
world journal of gastrointestinal oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 26
ISSN - 1948-5204
DOI - 10.4251/wjgo.v11.i12.1126
Subject(s) - medicine , cachexia , perineural invasion , pancreatic cancer , gastroenterology , midkine , immunohistochemistry , adenocarcinoma , biomarker , disease , oncology , pathology , cancer , growth factor , biochemistry , chemistry , receptor
Cachexia is responsible for the low quality of life in pancreatic adenocarcinoma (PDAC). The rapid disease progression and patient deterioration seems related to perineural invasion, but the relationship between cachexia and perineural invasion for the evolution of the disease has been rarely studied. As perineural invasion is difficult to be highlighted, a biomarker such as the neurotrophic factor Midkine (MK) which promotes the neuronal differentiation and the cell migration could be helpful. Also, Activin (ACV) has been described as cachexia related to PDAC. However, their role for assessing and predicting the disease course in daily practice is not known.